Irsogladine maleate (JP17); Gaslon N (TN). Formula. C9H7Cl2N5. C4H4O4. Exact mass. Mol weight. Structure, Mol file KCF file DB search. View and buy high purity Irsogladine maleate from Tocris Bioscience. PDE4 inhibitor; antiulcer agent. Description. You can increase or mucus to protect the stomach, gastric mucosal blood flow better and increase the resistance to gastric acid, I will often heal.

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Nozaki et al Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice malexte anti-gastric ulcer agent, irsogladine. N Engl J Med. Furthermore, the chemopreventive property of irsogladine maleate was examined in a Min mouse model of familial adenomatous polyposis. We hypothesized that combining aspirin administration with a gastric mucosal protectant would reduce the risk of gastrointestinal bleeding.

Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. In addition, there were no observed changes in organ weights that might have been attributable to toxicity. Free Radic Biol Med. The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: Don’t have an account?

In fact, to our knowledge, no descriptions of severe side effects of irsogladine maleate treatment have been reported in the literature.


Among the test reagents, the data from irsogladine maleate were best aligned with the purpose of this study. All of the free RCs detected in the liver samples taken from 0 A.

Compound Libraries Irsogladine maleate is also offered as part of the Tocriscreen Plus. Moreover, the levels of oxidative stress-related markers, reactive carbonyl species, in the livers of Min mice were clearly decreased following the irsogladune of irsogladine maleate. We calculated the dose of 5 and 50 ppm that corresponds to a human dose.

Table 2 The levels of RCs detected in liver samples of irsogladine maleate-treated or non-treated Min mice.

Further in vitro and in vivo experiments and clinical trials investigating the suppression of colon carcinogenesis by irsogladine maleate are needed to provide solid evidence of the chemopreventive effects of irsogladine maleate in the colon.

References References are publications that support the biological activity of the product. Associated Data Supplementary Materials oncotargets Therefore, the suppression of oxidative stress in Min mice by irsogladine maleate could be related to the reduction of intestinal tumorigenesis.

KEGG DRUG: Irsogladine maleate

Alpha-oxidation of fatty acids in higher plants. The small intestines were fixed, embedded and sectioned as Swiss rolls for further immunohistochemical examination using the avidin—biotin complex immunoperoxidase technique after heating with 10 mM citrate buffer irsgladine 6.

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This article has been cited by other articles in PMC. Annu Rev Cell Biol.

Irsogladine maleate (CAS 84504-69-8)

Structure, regulation and function of NF-kappa B. Thus, we aimed to identify an ideal gastric mucosal protectant with anti-oxidative stress and anti-intestinal tumorigenesis potential. Citations for Irsogladine maleate Citations are publications that use Tocris products. Create an account quickly and easily with your preferred social network account.

Volume nanoliter microliter milliliter liter. Moreover, 50 ppm irsogladine maleate seems no more effective than 5 ppm. Volume 1 nanoliter microliter milliliter liter.

Almost all polyps developed in the small intestine, with only a few developing in the colon. By signing up, you indicate that you have read and agree to the terms in our privacy policy. As a negative control, consecutive sections were immunostained without exposure to the primary Ab. The maximal number of polyps was observed in the size range up to 3. Please let us know.