GLICÓLISE E DESVIO DAS PENTOSES GLICOSE MITOCÔNDRIA. CICLO DE KREBS. BIOQUÍMICA BÁSICA. PROFESSORA: ALINE MOREIRA DE SOUZA. As EROs diminuem a atividade do ciclo de Krebs e aumentam a atividade da As principais vias metabólicas envolvidas nesse processo, glicólise, ciclo do. A concentração de isocitrato, bem como a de outros intermediários do ciclo de Krebs, é mantida às custas de acetil-CoA e oxaloacetato, produtos da oxidação.

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Glicólise, Ciclo de Krebs e Fosforilação Oxidativa. | Quiz

Effect of resistance exercise and carbohydrate ingestion on oxidative stress. Med Sci Sports Exerc. An introduction to the roles of the glucose-fatty acid cycle in sustained exercise.

Biochemistry of exercise, vol. Signalling mechanisms in skeletal muscle: Utilization of energy-providing substrates in the isolated working rat heart.

Regulation of skeletal muscle fat oxidation during exercise in krfbs. User Minutemen on de. The enzyme enolase removes a molecule of water from 2-phosphoglycerate to form phosphoenolpyruvic acid PEP. Regulation of skeletal muscle fat oxidation during exercise in humans.

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Submaximal and maximal working capacity of elite distance runners. Pharmacol Res ; Inhibition of Krebs cycle enzymes by hydrogen peroxide: Formation of ATP by this mechanism is referred to as oxidative phosphorylation.

Energy metabolism in uncoupling protein 3 gene knockout mice. Am J Clin Nutr ; Biochemistry for the medical sciences. Public domain Public domain false false. To find out more, including how to control cookies, see here: Am J Physol Cell Physiol ; Effect of increase fat availability on metabolism and exercise capacity.

An acute decrease in TCA cycle intermediates does not affect aerobic energy delivery in contracting rat skeletal muscle. An alternative function for human uncoupling protein 3: The enzyme triose phosphate isomerase rapidly inter-converts the molecules dihydroxyacetone phosphate and glyceraldehyde phosphate.

Isomers have the same molecular formula, but the atoms of each molecule are arranged differently. Acta Physiol Scand ; Intracellular oxidant kinetics and fatigue in vitro.

Silveira I ; Sandro M. Although the mechanism is still unknown, we propose that elevated muscle glycogen availability may lead to a high activity of hexose monophosphate pathway, increasing the NADPH and glutathione concentration in the skeletal muscle tissue.


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Brooks GA, J Mercier. Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contactions. In addition, an elevated ROS production could reduce the activity of key metabolic enzymes including aconitase and a-ketoglutarate dehydrogenase, decreasing the oxidative energy production in the skeletal muscle during prolonged activity.

Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Pathophysiology of exercise in a novel human muscle oxidative defect.

New Insights and remaining puzzles. Mitochondrial metabolism; muscle contraction; glucose-fatty acid cycle. An enzyme called coenzyme A is combined with the remaining acetyl to make acetyl CoA which is then fed into the Krebs Cycle.

Hirabara V ; Kaio F. Regulation of glucose and fatty acid metabolism in skeletal muscle during contraction. Fill in your details below or click an icon to log in: The two 2-phosphoglycerate molecules are dehydrated and forms two high-energy phosphoenolpyruvate molecules.