Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Cotula – Wikipedia

Introduction Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ]. Phillips Cotula pterocarpa DC. View at Google Scholar F. The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis pathways and inactivating the telomerase [ 6 ].

Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot. The plant is widely distributed in Morocco and is widely used in Moroccan traditional folk medicine as a cholagogue, antiseptic, diuretic, and astringent [ 12 ].

BioMed Research International

To date various bioactive compounds have been tried against cancer. Voucher specimens of both plants were deposited in the herbarium of cimerea Botany Department of this institution. Sports Turf Research Institute. Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed.

Indexed in Science Citation Index Expanded. In the genus was subdivided by George Bentham [5] into three sections. Views Read Edit View history.


Flavonoids from Cotula cinerea Del

For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. After filtration and evaporation of ethanol, the obtained aqueous solution was successively fractionated with hexane, ethyl acetate, and n -butanol.

Vogel Cotula filifolia Thunb. Burtt Cotula reptans Benth. Huile essentielle de Santolina africana Jord. Mouzdahir A Huile essentielle de Santolina africana Jord. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital. Table of Contents Alerts.

The extraction was achieved during six hours and the obtained oil yield 0. Clnerea main constituents cinnerea the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene. Abstract The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.

The obtained results showed that the cytotoxicity differed according to the used extract with an efficient effect of Cotula cinerea extracts compared to Salvia verbenaca. Due to its complex phytochemical composition, it is difficult to define a unique mechanism of its action on the used cell tumor. Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect.

Cinereaa, the explored extracts are complex mixtures containing several phytochemical compounds which could have different biological activities. Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. The noticed differences in the observed cytotoxicity of the investigated mixtures could obviously be due to the phytochemical composition of each extract. A preliminary phytochemical screening of the Cotula cinerea and Salvia verbenaca extracts showed the presence of polyphenols such as flavonoids and other secondary metabolites.


The collected aerial parts were left under shade at room temperature until complete drying. Showing of 22 references. Indeed, plants are rich sources cotulq new compounds from which some secondary metabolites have been shown to possess anticancer properties [ 5 — 7 ].

Those of Salvia verbenaca were collected on March at the locality cinerew Ain Aouda, in the Rabat region, Morocco. Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7]. On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with the lowest IC cknerea value The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil.

These compounds could act individually or cinnerea a synergic manner. References Publications referenced by this paper. Material and Methods 2. The maceration process was repeated twice during 24 h each in order to achieve an exhaustive extraction.

Nevertheless, the Cotula cinereea essential oil can act through various mechanisms. The Royal Society of New Zealand. Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity.