Download scientific diagram | – Cnidoscolus quercifolius plant. from publication: Análise Química e Bromatológica da Forragem da Faveleira (Cnidoscolus. PDF | Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential. The Cnidoscolus quercifolius (Pohl) popularly known as “favela” or “faveleira” is a forager that is part of the native species from the caatinga.

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The excess of oxidative stress which leads to organic decay cnidosccolus mitigated or even prevented by antioxidants-based therapies. The determination of the Minimum Inhibitory Concentration of Fungi MIC-f was obtained with a stereoscope, verifying the lower concentration of samples capable of inhibiting the growth of the microorganism, after 5 days of incubation.

For this reason, the present study focuses on the assessment of the therapeutic potential of this plant, by investigating its possible antioxidant, antimicrobial, and inhibitory activity of the acetylcholinesterase enzyme AChEas well as the toxicity of the methanolic extracts from three parts of Cnidoscolus quercifolius Pohl. View at Google Cnidoscoluw F.

The authors expect to develop a new herbal product, resulting in lower production costs and that, consequently, could be commercialized in more accessible form to the population, highlighting the risk reduction of contraindication of this category of medications. Standing out among these auspicious outcomes are the suercifolius effects, the bactericidal and fungicidal potential, and the inhibitory effect against the acetylcholinesterase enzyme in two extracts tested, which showed no significant difference when compared with the reference drug.

Thus, the antioxidant therapies used in a large number of illnesses related to the generation of free radicals, such as cancer, aging, atherosclerosis, ischemia, quercifoliuss, and neurodegenerative diseases, seem to be promising [ 35 ].

The importance of medicinal plants in solving the health problems cnidoscoluss the world is gaining more and more attention.

Cnidoscolus quercifolius

In many cases, the procedures of modern medicine and popular medicine are supplemental and constitute an effective form of primary health care, which may supplement the treatment usually employed in the lower income population. It is widely used as fodder for cattle and small ruminants, mainly in the dry cnidoscolis. This document aims to ensure secure access to phytotherapic remedies, considering traditional knowledge on medicinal quercifolkus, as well as promote research and encourage the development querrcifolius technology and innovation, stimulating the use of medicinal plants in different stages of the production chain, ultimately fostering the sustainable use of biodiversity.

The MIC was studied for bacterial strains that were sensitive to the methanolic extracts of faveleira in the agar diffusion method Table 2. To determine the biological activities the authors conducted investigation of antioxidant queercifolius antimicrobial activities, inhibition capacity of the acetylcholinesterase enzyme, and initial assessment of toxicity of the extracts.


TLC evaluated inhibition of acetylcholinesterase enzyme AChEin accordance with the methodology described by Ellman et al. Its xerophile character allows the plant to grow and reproduce, even in periods of prolonged droughts, thus contributing to keep the balance of the ecosystem, mitigating environmental degradation. Chemical tests were performed using specific reagents, observing color changes or formation of precipitate, characteristic for each class of substances. It is a rustic plant of rapid growth, belonging to the Euphorbiaceae family [ 13 ] and Cnidoscolus genus [ 14 ].


Ahmad and Beg [ 44 ] believe that the antimicrobial effect of vegetal extracts is largely due to the presence of flavonoids in their composition, thus corroborating the results found for the C. In a test of toxicity against Artemia salinaconducted by Fabri et al. Among these is the faveleiraused in northeastern Brazil. Hoffm presented relevant antioxidant activity and phenolic compounds in the species, suggesting that C.

Cnidoscolus quercifolius – Wikipedia

Man has long been using plants to promote health, in the belief that they carry beneficial substances for a healthy existence.

With the aid of a light source, the hatched larvae were attracted to the lightened vessel part and were collected with a Pasteur pipette and then transferred to a beaker with saline water. Despite this unique condition, there was not enough incentive to direct local preservation botanical studies [ 8 ].

To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential against several tumor strains. Antioxidant Activity The in vitro antioxidant activity of the extracts was determined using the 1,1-diphenylpicrylhydrazyl DPPH method, as previously reported by Brand-Williams et al.

The World Health Organization WHO has recognized and recommended the dissemination of traditional knowledge and use of phytotherapic medicines. There was no inhibitory response from the extracts tested against Escherichia coli and Klebsiella pneumoniae strains, thus demonstrating that the methanolic extracts of faveleira showed better inhibition against strains of Gram-positive bacteria.

Matos, Plantas Medicinais no Brasil: In Brazil, the first Europeans who settled in the land ran across a large quantity of medicinal plants used by the indigenous populations who lived here.

These cniroscolus samples of crude extracts and may therefore be considered a meaningful result, suggesting the need to isolate the compounds responsible for sequestering the free radicals, thus achieving an index even closer to the default. Evidence-Based Complementary and Alternative Medicine. In the bark of C. In the evaluation of toxicity of methanolic extracts of C. View at Google Scholar L.


The United States and Germany rank among the biggest consumers of natural products from Brazil. In a study conducted with the oil from the seeds and extract from the leaves of the faveleira, Ribeiro [ 45 ] found reduced mycelial growth and germination of conidia of F.

The halos quercifoliuz measured and compared with the halo formed by physostigmine, a standard alkaloid.

Halos of inhibition of acetylcholinesterase enzyme by the methanolic extracts of C. Oxidative stress may occur when there is limitation in the availability of antioxidants. The results suggest that the substances present in faveleira Cnidoscolus cnidoscolhs root bark extract have a cytotoxic potential querfifolius several tumor lines, showing a broader antitumour potential, and in addition no adverse to healthy cells.

This study did not detect alkaloids in any of the C. Peixoto Sobrinho et al.

Evidence-Based Complementary and Alternative Medicine

There was no statistically significant difference between the LME and RBME with the reference drug Eserinewhich represents a new source of bioactive compounds with potential as acetylcholinesterase inhibitor Figure 2. Souza [ 55 ] describes that the absence of toxicity can be an advantage for the possibility of using isolated substances in developing herbal medicines for use in humans.

One of the first AChE inhibitors used was physostigmine, an alkaloid isolated from a plant of the Leguminosae family, although this alkaloid is no longer used clinically, due to its short half-life.

The high-performance liquid chromatography with diode-array detection and 1 H and 13 C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract.

Several studies have shown the use of Artemia salina to evaluate the toxicity of extracts, of isolated and purified substances of medicinal plants [ 3151 — 54 ], thus decreasing the use of animals for experimentation.

Therefore, the root bark extract of Cnidoscolus quercifolius has a possibility of use for anticarcinogenic therapies.

To analyze the significance of the differences between the samples the authors used Variance Analysis ANOVA followed by the Newman-Keuls comparison test, being considered significant.

The in vitro antioxidant activity of the extracts was determined using the 1,1-diphenylpicrylhydrazyl DPPH method, as previously reported by Brand-Williams et al. According to Ribeiro and Brito [ 15 ], the faveleira can be used for forestation, recovery of querciffolius areas, animal and human consumption, medicine, timber, and energy.

The lethality assay against Artemia sp.