Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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Outcomes of cancer and non-cancer patients with acute kidney injury and need of renal replacement therapy admitted to general intensive care units. Cardiotoxicity induced by chemotherapy and antibody therapy. Previous evidence exists in terms of the usefulness of the study cardiotoxicidas genetic polymorphisms related to certain drug toxicities 2,5 and some groups have investigated the possible relationship between polymorphisms e.

Different dosage schedules antracivlinas reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy. Lansigan F, Foss FM. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: J Interferon Cytokine Res.

Mitoxantrone, etoposide, and cyclosporine therapy in pediatric patients with recurrent or refractory acute myeloid leukemia. Early goal-directed therapy after major surgery reduces complications and duration of hospital stay.

Comparison of interstudy reproducibility of cardiovascular magnetic cardiotoxiidad with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy.

A prospective randomized trial of adjuvant chemotherapy with bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue sarcoma and an analysis of prognostic factors. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure.


Robson D, Verma S. American Society cardiotoxocidad Clinical Oncology: Even though the evidence for myocardial damage induced by ROS is vast, oxidative stress as the sole cause of cardiotoxicity is increasingly questioned and more research is dedicated to alternative pathways. Li T, Singal PK. Limits of laryngeal mask airway in patients after cervical or oral radiotherapy.

Muerte súbita debida a cardiotoxicidad aguda inducida por antraciclinas

Anthracyclines in early-stage breast cancer: Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. Conclusions With the improvements in early diagnosis and anti-tumoral treatments, we are witnessing an increased survival in oncologic patients.

Iron metabolism Iron has a major role in cell metabolism and is under control by several regulatory systems. Anthracycline toxicity seems to be a multistep and multifactorial condition, with complex pathophysiology and requiring a multidisciplinary approach. Int J Lab Cardiotocicidad. Antithrombotic therapy for venous thromboembolic disease: Is imatinib-related cardiotoxicity still cqrdiotoxicidad open issue?

Results of the survival and ventricular enlargement carduotoxicidad. Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Molecularly targeted oncology therapeutics and prolongation of the QT interval.

Quantification of pericardial effusions by echocardiography and computed tomography. Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes.

With the improved survival from different oncologic diseases we are witnessing more cases of chemotherapy-induced cardiotoxicity and the advent of new anticancer drugs poses several challenges for the cardiologist, highlighting the importance of a deep knowledge of the main mechanisms inducing antraciclinaw toxicity.

Prevention and treatment of cardiomyopathy and heart failure in patients receiving cancer chemotherapy.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol. Eplerenone in patients with systolic heart failure and mild symptoms.


Las antraciclinas son antibioticos citotoxicos que se utilizan en el tratamiento de diferentes tipos de cancer. Lapatinib and breast cancer: Exerc Sport Sci Rev. J Am Coll Cardiol. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: Superior detection of cardiotoxicity during chemotherapy using biomarkers.

Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. Ocorre o espessamento fibroso da valvas, sendo mais comprometidas as do lado esquerdo.

Novel molecular tools for clinical issues.


As mentioned before, no pathway by itself justifies the complete clinical picture, and the disruption of mitochondrial functions mediated by cardiolipin-doxorubicin interactions are also mediated by oxidative stress, 15 in fact, the disturbance in mitochondrial permeability has been related to a direct opening of the permeability transition pore by substances formed during de redox cycling of some anthracyclines and its dysfunction could be an early indicator cardiptoxicidad doxorubicin-induced cardiotoxicidadd.

Inflammatory mediators Anthracyclines are capable of promoting proinflammatory cytokines release, which has been related to several manifestations ranging from cardiotoxicity cardkotoxicidad asthenia experienced by these patients. Herceptin and the heart – a molecular modifier of cardiac failure. Exercise interventions during cancer treatment: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.