PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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These findings are in agreement to findings of Dharmasiri et al. This article has been cited by other articles in PMC. Reactive oxygen species are implicated in various inflammatory disorders. The anti-inflammatory activity in inflammaatory dose was also comparable with Ibuprofen mg kg -1 B.

J of Med and Aromat Plant Acticity Kundnani College of Pharmacy. Therefore, reduction of oxidative stress by anti-lipoperoxidative activity might possibly be the mechanism of anti-inflammatory action of VN in model of sub-acute inflammation. Support Center Support Center. A herbarium specimen of this plant has been deposited at Principal K.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

State of the art. Indian Journal of Natural Products and Resources 4: Group I received distilled water and served as control. Steam distillate of the leaves can be used as stomachic, purgative, febrifuge and antiemetic [ 8 ]. Proceedings fo the international workshop, Lucknow: DX 7 days, orally as shown in Table 2.


Antioxidant and Antiinflammatory Activity of Vitex negundo

Stabilization of the Prussian blue colour in the determination of polyphenols. The paw edema volume was measured with the help of plethysmometer at zero hour. To this reaction mixture thiobarbituric acid was added and the mixture was boiled for 15 min. After washing, tissue homogenate was prepared in 10 volumes of ice-cold potassium chloride by homogenizing qctivity 15 min.

The easy availability of this neundo, coupled with its reported usefulness in arthritic disorders prompted us to further explore its antiinflammatory and antioxidant activity.

The total polyphenols were estimated as gallic acid equivalents. Absorbance of the resulting pink chromogen was recorded at nm. The tissue damage then provokes inflammatory response by the production of mediators and chemotactic factors 4.

The ethno medical use of V. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

Antioxidant and antiinflammatory activity of Vitex negundo. For mechanism of action: Crushed leaves are applied externally cures skin eruption and to relieves burn.

More over anti-ulcer activity of VN reported by Sahni et al. Although, negundk of VN have been investigated for its anti-inflammatory activity in past Telang et al.


The pink colour complex of thiobarbituric acid reacting substances was monitored at nm 8 — Gallic acid and 1,1-diphenylpicrylhydrazyl was procured from Sigma Aldrich Co.

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The activity was evaluated by using carrageenan induced paw edema in rats. The anti-inflammatory activity was studied by using carrageenan induced paw edema in rats. MDA is a metabolic product of lipid peroxidation, the level of which is increased in oxidative stress. The anti-inflammatory activity in this dose of the test drug was comparable to phenylbutazone mg kg -1 PO.

Effect of Vitex negundo extract on oxidative stress by plasma estimation of malondialdehyde MDA. Free Radical scavenging activity of Syzygium cumuni and Ficus bengalensis plants used in Ayurveda for Diaibetus mellitus. Carrageenin induced hind paw edema and cotton pellet granuloma test in albino rats were employed to study the anti-inflammatory activity of Vitex negundo VN leaf extract.

Khare CP Indian medicinal plants an illustrated dictionary. Present findings are in agreement with the studies of Jana et al. It belongs to the family Verbanaceae [ 4 ]. C Harinath, Director and Head J. J Lab Clin Med.