Cefazolin for injection and other antibacterial drugs, Cefazolin for injection should be A Pharmacy Bulk Package is sterile dosage form for parenteral use that. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefazolin for Cefazolin for Injection, USP is a semi-synthetic cephalosporin for parenteral administration. .. For IV Administration: See package insert. Page 2 of PRODUCT MONOGRAPH. Pr. Cefazolin for Injection USP. THERAPEUTIC CLASSIFICATION. Antibiotic. ACTION AND CLINICAL.
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Antibiotics administered for at least 4 hours before delivery have been found to be highly effective at preventing the transmission of Group B Streptococcus.
Neonates younger than packgae weeks gestation and 14 days and older. Repeat dose intraoperatively 4 hours after preoperative dose if surgery still in progress. It is distributed into most body tissues and fluids including gallbladder, liver, kidney, bone, myocardium, sputum, bile, and pericardial, pleural, and synovial fluids.
Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Since safety for use in premature infants and inseert neonates has not been established, the use of ANCEF in these patients is not recommended.
Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Appropriate culture and anceg studies should be performed to determine susceptibility of the causative organism to ANCEF. All cephalosporins, including cefazolin, may rarely cause hypoprothrombinemia and have the potential to cause bleeding. Lysis is mediated by bacterial cell wall autolytic enzymes i. Intravenous or Intramuscular dosage.
Cefazolin is primarily eliminated by the kidneys and is not metabolized by the liver.
Moderate Nephrotoxicity associated with cephalosporins may be potentiated by concomitant furosemide therapy. Baxter’s BioSurgery business unit offers zncef comprehensive line of biologics, devices and combination products.
CEFAZOLIN | LHSC
Shake well until dissolved. Animal data reveal no teratogenic effects. Reconstitute powder with Sterile Water for Injection. Reconstituted solution is stable for 24 hours at room temperature or 10 days refrigerated. Intermittent hemodialysis For adult patients, mg to 1 g IV every 24 hours is recommended.
Cefazolin is FDA-approved for contaminated or potentially contaminated procedures, including vaginal hysterectomy and cholecystectomy in high-risk patients, as well ancdf in surgical patients in whom infection at the operative site would present a serious risk e. In the colon, overgrowth of Clostridia anxef exist when normal flora is altered subsequent to antibacterial administration. Where can I go for care during the holidays?
The serum half-life for cefazolin is approximately 1. Elimination half-life is 1—2 hours in patients with normal renal function. Cefazolin distributes into pxckage milk in low concentrations. Perioperative Prophylactic Use To prevent postoperative infection in contaminated or potentially contaminated surgery, recommended doses are:.
Respiratory Tract Infections Due to S. Systemic antibiotics should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease. Reconstituted solutions may range in color from pale yellow to yellow without a change in inert. Perioperative antisepsis with povidone-iodine is recommended.
These include anesthetic gases, or inhaled anesthetics, and anesthesia-related critical care drugs. Clinical practice guidelines recommend cefazolin monotherapy for cardiothoracic, gastrointestinal, biliary tract, hernia repair, clean head and neck with prosthesis, neurosurgical, urogynecology, orthopedic, vascular, certain transplantation, and plastic surgery procedures.
During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances.
Sodium anxef Magnesium oxide; Anhydrous citric acid: Guidelines recommend cefazolin as an alternate therapy for highly penicillin-susceptible streptococcal infections; treat for 4 weeks for native valve endocarditis NVE and for 6 weeks or prosthetic valve endocarditis PVE. According to OBRA, use of antibiotics should be limited to confirmed or suspected bacterial infections. Cefazolin is excreted renally; because geriatric patients are more likely to have decreased renal function, inserr should be taken in dose selection and it may be useful to monitor renal function.
The serum half-life for cefazolin is approximately 2 hours following IM administration.