AGLUTININAS FRIAS PDF

Request PDF on ResearchGate | Síndrome de aglutininas frías y púrpura trombocitopénica autoinmune: Un caso inusual de síndrome de. Abstract. ARANGO, Marcos; ARENAS, Mario and MARTINEZ, Octavio. Mycoplasma pneumoniae pneumonia complicated by cold agglutinin hemolytic anemia. QUINTANILLA-GALLO, Júvel; MARCHENA- PICADO, Margarita and GOURZONG- TAYLOR, Charles. Síndrome aglutininas frías. Acta méd. costarric [ online].

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Autoimmune Hemolytic Anemia

It occurs more frequently after the age of Cold agglutinin disease manifests as acute or chronic hemolytic anemia, with associated pallor and fatigue.

A cold environment or a concurrent infection may trigger or exacerbate the condition, and episodes of acute hemolysis with hemoglobinemia and hemoglobinuria are more common in winter.

The disease may appear abruptly with anemia and hemoglobinuria, or onset may be more gradual and insidious.

Cold agglutinin disease can be primary idiopathic or secondary, caused by an underlying condition, such as infection Mycoplasma pneumoniaelymphoproliferative disorders, systemic autoimmunity or neoplasm. Idiopathic agultininas lymphoma-associated cold AIHA tend to be chronic while infections tend to cause an acute disease.

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In some cases, the diagnosis is made by chance on a standard complete blood count CBC detecting abnormal agglutination of the red blood cells.

Diagnosis is based on clinical agoutininas laboratory evidence of hemolytic anemia and the detection of autoantibodies, specifically IgM, with rrias direct anti-globulin test DAT, C3 positive pattern with the presence of circulating cold agglutinins inthe serum.

In secondary cases, lymphocytosis, with the presence of atypical lymphocytes on the smear, can be found in peripheral blood.

Patients with few clinical symptoms and mild anemia may not require treatment but only avoidance of cold. Keeping the patient warm may be sufficient treatment. The disease is usually refractory to corticosteroids.

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Rituximab may be an option for treatment in some cases. In the presence of underlying lymphoma, chlorambucil or oral cyclophosphamide may be helpful. The disease has a chronic course and the outcome is usually benign, except in patients with recurrent episodes of severe anemia or in whom the underlying B-cell lymphoma has an aggressive course.

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Summary and related texts. Check this box if you wish to receive a copy of your message. Clinical description It occurs more frequently after the age of Etiology Cold agglutinin disease can be primary idiopathic or secondary, caused by an underlying condition, such as infection Mycoplasma pneumoniaelymphoproliferative disorders, systemic autoimmunity or neoplasm.

Diagnostic methods In some cases, the diagnosis is made by chance on a standard complete blood count CBC detecting abnormal agglutination of fias red blood cells.

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Differential diagnosis The differential diagnosis for cold agglutinin disease is mixed AIHA see this term.

Translation of “aglutininas frías” in English

Management and treatment Patients with few clinical symptoms and mild anemia may not require treatment but only avoidance of cold. Prognosis The disease has a chronic course and the outcome is usually benign, except in patients with recurrent episodes of severe anemia or in whom the underlying B-cell lymphoma has an aggressive course. Additional information Further information on this disease Classification s 1 Gene s 0 Clinical signs and symptoms Publications in PubMed Other website s 3.

Health care resources for this disease Expert centres Diagnostic tests 0 Patient organisations 4 Orphan drug s 0.

aglutininas frías – Translation into English – examples Spanish | Reverso Context

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